Publications

Selected Papers Authors Citation
Effects of lactoferrin on the immune response modified by the immobilization stress M. Zimecki, K. Artym, G Chodaczek, M Kocieba, M Kruzel 2005 Pharmacol Rep. Nov-Dec;57(6):811-7
Lactoferrin Accelerates Reconstitution of the Humoral and Cellular Immune Response During Chemotherapy-induced Immunosuppression and Bone Marrow Transplant in Mice J. Artym, M. Zimecki, J. Kuryszko, M.L. Kruzel 2005 Stem Cells and Development. 14:548–555.
Lactoferrin augments BCG vaccine efficacy to generate T helper response and subsequent protection against challenge with virulent Mycobacterium tuberculosis Shen-An Hwang, Marian L. Kruzel, Jeffrey K. Actor 2005 International Immunopharmacology 5. 591–599
Effect of lactoferrin on the methotrexate-induced suppression of the cellular and humoral immune response in mice Artym J. Zimecki M. Kruzel M. 2004 Anticancer Res. Nov-Dec;24(6):3831-6.
Protective effects of lactoferrin in Escherichia coli-induced bacteremia in mice: Relationship to reduced serum TNF alpha level and increased turnover of neutrophils M. Zimecki, J. Artym, G. Chodaczek, M. Kocieba and M.L. Kruzel 2004 Inflamm. res. 53. 292–296
Normalization of peripheral blood cell composition by lactoferrin in cyclophosphamide-treated mice. Artym J. Zimecki M. Kruzel M. 2004 Medical Science Monitor. 10(3):BR84-9, Mar.

Role of lactoferrin in development of inflammation

Kruzel ML. 2003 Postepy Hig Med Dosw;57(4):377-404.
Bovine lactoferrin decreases histopathological changes in the liver and regulates cytokine production by splenocytes of obstructive jaundiced rats Zimecki M. Dawiskiba J. Zawirska B. Krawczyk Z. Kruzel M. 2003 Inflammation Research. 52(7):305-10, Jun.
Orally administered lactoferrin restores humoral immune response in immunocompromised mice Jolanta Artym, Michal Zimecki, Maria Paprocka, Marian L. Kruzel 2003 Immunology Letters 89; 9/15

Immunomodulation by nutrition: a new challenge for milk-derived proteins and peptides

Marian L Kruzel 2003 Anti-Aging Therapeutics. Chapter 34

Reconstitution of the cellular immune response by lactoferrin in cyclophosphamide-treated mice is correlated with renewal of T cell compartment

Artym J, Zimecki M, Kruzel ML. 2003 Immunobiology. 207(3):197-205.
Differential effects of prophylactic, concurrent and therapeutic lactoferrin treatment on LPS-induced inflammatory responses in mice M. L. KruzelL, Y. Harari, D. Mailman, J. K. Actor, M. ZimeckiI 2002 Clin Exp Immunol ; 130 :25–31

Lactoferrin and immunologic dissonance: clinical implications

Kruzel ML, Zimecki M. 2002 Arch Immunol Ther Exp (Warsz). 50(6):399-410.
Lactoferrin immunomodulation of DTH response in mice Jeffrey K. Actor, Shen-An Hwang, Margaret Olsen, Michal Zimecki , Robert L. Hunter Jr., Marian L. Kruzel 2002 International Immunopharmacology 2; 475– 486

The adjuvant activity of lactoferrin in the generation of DTH to ovalbumin can be inhibited by bovine serum albumin bearing alpha-D-mannopyranosyl residues

Kocieba M. Zimecki M. Kruzel M. Actor J. 2002 [Journal Article] Cellular & Molecular Biology Letters. 7(4):1131-6, .
Lactoferrin-induced up-regulation of zeta (zeta) chain expression in peripheral blood T lymphocytes from cervical cancer patients Frydecka I. Zimecki M. Bocko D. Kosmaczewska A. Teodorowska R. Ciszak L. Kruzel M. Wlodarska-Polinsk J. Kuliczkowski K. Kornafel J. 2002 Anticancer Research. 22(3):1897-901, May-Jun.
Immunoregulatory activities of lactoferrin in the delayed type hypersensitivity in mice are mediated by a receptor with affinity to mannose Zimecki M. Kocieba M. Kruzel M. 2002 Immunobiology. 205(1):120-31, Mar.
Lactoferrin regulates the immune responses in post-surgical patients Zimecki M. Wlaszczyk A. Wojciechowski R. Dawiskiba J. Kruzel M. 2001 Archivum Immunologiae et Therapiae Experimentalis. 49(4):325-33.

Lactoferrin regulates proliferative response of human peripheral blood mononuclear cells to phytohemagglutinin and mixed lymphocyte reaction

Zimecki M, Stepniak D, Szynol A, Kruzel ML. 2001 Arch Immunol Ther Exp (Warsz). 49(2):147-54.
Lactoferrin protects gut mucosal integrity during endotoxemia induced by lipopolysaccharide in mice Marian L. Kruzel, Yael Harari, Chung-Ying Chen, Gilbert A. Castro. 2000 Inflammation, Vol. 24, No. 1, 0360-3997.Plenum Publishing Corporation.

Systemic or local co-administration of lactoferrin with sensitizing dose of antigen enhances delayed type hypersensitivity in mice

Michal Zimecki and Marian L. Kruzel 2000 Immunology Letters 74; 183–188

Lactoferrin increases the output of neutrophil precursors and attenuates the spontaneous production of TNF-alpha and IL-6 by peripheral blood cells Abstract

Zimecki M, Spiegel K, Wlaszczyk A, Kubler A, Kruzel ML. 1999 Arch Immunol Ther Exp (Warsz);47(2):113-8.

The gut. A key metabolic organ protected by lactoferrin during experimental systemic inflammation in mice Abstract

Kruzel ML, Harari Y, Chen CY, Castro GA. 1998 Adv Exp Med Biol. 443:167-73.

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